A 47-year-old man with a history of intermittent panic disorders presents to his primary care physician desiring therapy. He has no other pertinent past medical or surgical history. Physical examination of the heart, lungs, and abdomen are within normal limits. What is the most appropriate treatment for this patient?
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Question 2 of 107
Enalapril differs from captopril in that
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Question 3 of 107
What are obidoxime and pralidoxime?
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Question 4 of 107
Main effect of sulfinpyrazone in hyperuricemia is
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Question 5 of 107
A woman in the 28th week of pregnancy with pregnancy-induced hypertension (BP 150/95 mmHg) should receive
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Question 6 of 107
Ketamine, a general anaesthetic agent can be administered by
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Question 7 of 107
Which of the following drugs can be used as an alternative to lithium in mania and bipolar illness?
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Question 8 of 107
An 83-year-old woman with Parkinson's disease is currently being treated with carbidopa/levodopa, but her Parkinson's symptoms are worsening. She has normal liver function and no history of liver disease. Selegiline is added to her regimen. How does selegiline help in Parkinson's disease?
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Question 9 of 107
The pKa of lidocaine is 7.9. In infected tissue at pH 6.9, the fraction in the ionized form will be
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Question 10 of 107
Propofol
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Question 11 of 107
A 65-year-old man develops new onset of symptoms of urinary incontinence and cogwheel muscle rigidity. Evaluation of bladder function reveals sphincter bradykinesia. He has begun on treatment with levodopa. Which of the following effects should the physician warn this patient of?
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Question 12 of 107
A 45-year-old woman with chronic anxiety presents to her primary care physician for follow-up. She currently takes Librium 10 mg three times per day. Important warning considerations for use of this medication include which of the following?
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Question 13 of 107
Accidental poisonings are common with both aspirin and ibuprofen. In overdose, aspirin is more likely to cause
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Question 14 of 107
A 72-year-old man is brought to his physician by his son. The son complains that this patient has been becoming forgetful, confused, moody, and aggressive over the past few months. Which of the following neurotransmitter changes is characteristic of Alzheimer's disease?
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Question 15 of 107
Concerning the proposed mechanisms of action of antidepressant drugs, which one of the following statements is accurate?
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Question 16 of 107
A drug that produces increased contraction of the sphincter iridis by local application is a
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Question 17 of 107
Lithium toxicity may manifest as
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Question 18 of 107
The PPAR-γ receptor that is activated by thiazolidinediones increases tissue sensitivity to insulin by:
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Question 19 of 107
The primary site of action of tyramine is
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Question 20 of 107
Corticosteroids should be avoided in all the following EXCEPT:
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Question 21 of 107
Which of the following enzymes is ultimately responsible for the production of prostaglandins associated with inflammatory reactions?
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Question 22 of 107
Which one of the following drugs is most often associated with hypotension caused by histamine release?
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Question 23 of 107
Which of the following statements regarding procaine, a local anaesthetic agent is not correct.
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Question 24 of 107
The use of morphine is contraindicated in all the following conditions EXCEPT:
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Question 25 of 107
Which of the following narcotics has the longest duration of effect?
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Question 26 of 107
Opioid analgesics must be used with caution in several clinical situations. For morphine, such situations do not include
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Question 27 of 107
Morphine has high affinity for the following opioid receptor(s).
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Question 28 of 107
The following drug is effective in chlorpromazine-induced parkinsonism.
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Question 29 of 107
Propranolol and hydralazine have which of the following effects in common?
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Question 30 of 107
Which one of the following drugs can cause hypotension because it can block alpha-adrenergic receptors on vascular smooth muscle cells?
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Question 31 of 107
Consumption of alcoholic beverages, even in moderate amounts, is contraindicated for the following category of subjects except
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Question 32 of 107
Barbiturate-induced enzyme induction facilitates metabolism of
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Question 33 of 107
Aspirin is contraindicated in children suffering from influenza or similar viral infections because of increased risk of
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Question 34 of 107
Chlorpromazine is a phenothiazine derivative having a
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Question 35 of 107
The compound most likely to lower circulating leukotriene levels is
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Question 36 of 107
Regarding temazepam, all of the following are true EXCEPT
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Question 37 of 107
A 34-year-old man suffers a seizure while in a shopping mall. Witnesses tell the paramedics that the individual lost consciousness and then had rapid contraction and relaxation of his extremities. He then awoke and was confused. What is the most likely diagnosis?
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Question 38 of 107
The anti-cholinesterase with the shortest duration of action is
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Question 39 of 107
Regarding local anaesthetic agents, which statement is true?
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Question 40 of 107
Sodium valproate should be used with caution in young children because they are particularly at risk of developing the following adverse effect
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Question 41 of 107
A 7-year-old boy is brought to the clinic by his mother for a well-child checkup. Physical exam is normal, and he is in no acute distress. A few months ago, he started taking atomoxetine for attention-deficit/hyperactivity disorder. His mother has been pleased with the results but has one complaint that the physician immediately recognizes as a common side effect of atomoxetine. Which of the following is most likely the mother's complaint?
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Question 42 of 107
The most common symptom of hemorrhoids is
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Question 43 of 107
A 53-year-old man comes to clinic for depression. He has had decreased interest and a depressed mood for the past 6 months. He also smokes half a pack of cigarettes a day and thinks that if he could quit, that would help his mood as well. What is the most appropriate treatment for his depression and cessation of smoking?
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Question 44 of 107
The following statements about carbidopa is CORRECT:
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Question 45 of 107
Digitalis-induced increase in refractory period of myocardial fibers is most consistent and pronounced in the
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Question 46 of 107
Which of the following is true of nitrous oxide?
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Question 47 of 107
Which of the following drugs is expected to cause anticholinergic adverse effects in the elderly?
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Question 48 of 107
A patient with CHF on furosemide and digoxin developed UTI. Which antimicrobial should be avoided?
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Question 49 of 107
When initiating T4 therapy for an elderly patient with long-standing hypothyroidism, it is important to begin with small doses to avoid:
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Question 50 of 107
The local anesthetic having high cardiotoxic and arrhythmogenic potential is
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Question 51 of 107
An FDA-approved ingredient for protecting teeth against sensitivity is
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Question 52 of 107
Intermittent administration of PTH produces which of the following?
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Question 53 of 107
Ethyl alcohol (EtOH) is administered to patients who have ingested either ethylene glycol or methanol because EtOH
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Question 54 of 107
The dopamine D2 receptor has the following feature.
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Question 55 of 107
A 68-year-old man presents to the emergency department with worsening chest pain. He has a history of congestive heart failure and currently takes digoxin. Physical examination reveals an acutely ill man who is tachypneic. His room air pulse oximetry is 90%. Pulmonary auscultation reveals bilateral wheezing. Neck examination reveals jugular venous distension. Which one of the following is the most appropriate treatment for this patient?
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Question 56 of 107
A previously healthy 50-year-old woman begins to suffer from slowed mentation and develops writhing movement of her tongue and hands. In addition, she has delusions of being persecuted. The most appropriate drug for treatment is
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Question 57 of 107
Psychic depression can be treated by the following:
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Question 58 of 107
Levodopa and carbidopa combination is used to treat Parkinsonian disease because carbidopa
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Question 59 of 107
Lower doses of naloxone are required to
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Question 60 of 107
Fetal alcohol syndrome is characterized by
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Question 61 of 107
Which of the following is the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity?
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Question 62 of 107
Concurrent use of which of the following may lead to similar effects seen in patients who are administered disulfiram after the ingestion of alcohol
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Question 63 of 107
Which of the following medications would be considered first-line monotherapy for the treatment of bipolar disorder?
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Question 64 of 107
L-Dopa can be used to treat which of the following:
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Question 65 of 107
Which neurotransmitter has the maximum number of receptor subtypes?
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Question 66 of 107
You are on your way to take an examination and you suddenly get an attack of diarrhea. If you stop at a nearby drugstore for an over-the-counter opioid with antidiarrheal action, you will be asking for:
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Question 67 of 107
Fenton reaction refers to the formation of
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Question 68 of 107
Systemic corticosteroid therapy is not used routinely and is reserved only for severe cases of
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Question 69 of 107
Adverse effects of metformin include all of the following EXCEPT:
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Question 70 of 107
Which drug is contraindicated in gout despite its anti-inflammatory action?
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Question 71 of 107
Which of the following glucocorticoids is a prodrug:
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Question 72 of 107
Morphine administration leads to
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Question 73 of 107
The following is a selective COX-2 enzyme inhibitor:
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Question 74 of 107
What is true about the sensitivity of nerve fibres to local anaesthetics?
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Question 75 of 107
Which one of the following pairs of drug: indication is accurate?
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Question 76 of 107
Which loop diuretic is more likely to have oto toxicity?
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Question 77 of 107
A 61-year-old woman is going on a cruise and is afraid that she will develop motion sickness during the trip. She is given a prescription for scopolamine patch. She has no other medical problems and has never had surgery. On the first day of the trip, the boat is rocking heavily, and the patient is nauseous and she applies the patch. Instead of being sedated, she actually became very excited and agitated. What is the most likely explanation for these findings?
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Question 78 of 107
Following 5-HT receptors is a ligand-gated ion channel
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Question 79 of 107
Pilocarpine is used in
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Question 80 of 107
Which of the following drug side effects is incorrect?
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Question 81 of 107
The following drug is used to reverse the CNS depression produced by diazepam
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Question 82 of 107
The activity of which of the following drugs is dependent on a p-phenyl-N-alkylpiperidine moiety?
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Question 83 of 107
Trazodone (Desyrel) is used primarily as a (an)
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Question 84 of 107
Which of the following antipsychotic medications has the greatest potential for extrapyramidal side effects?
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Question 85 of 107
The following drug is used to induce ovulation:
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Question 86 of 107
A young male patient is brought to the emergency room of a hospital suffering from an overdose of cocaine following intravenous administration. His symptoms are unlikely to include
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Question 87 of 107
A drug that is used in the treatment of parkinsonism and will also attenuate reversible extrapyramidal side effects of neuroleptics is
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Question 88 of 107
Which anticonvulsant drug requires therapeutic monitoring of Phenobarbital serum levels as well as its own serum levels?
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Question 89 of 107
Zolpidem interacts with
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Question 90 of 107
In the treatment of hypertension, beta-adrenergic blockers have the following advantage
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Question 91 of 107
A very common side effect of morphine is
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Question 92 of 107
Neostigmine is beneficial in cobra envenomation because
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Question 93 of 107
A 34-year-old woman with multiple sclerosis presents with uncontrollable muscle spasms. The physician prescribes tizanidine to help control the spasms. Tizanidine's mechanism of action is most similar to which of the following drugs?
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Question 94 of 107
Hemicholinium modifies Ach metabolism by
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Question 95 of 107
The following is a selective COX-3 enzyme inhibitor:
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Question 96 of 107
There are major differences in the anatomical arrangement of neurons, which lead to variations of the functions in each division of the nervous system. Which of the following features describes the parasympathetic nervous system?
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Question 97 of 107
Following is an irreversible inhibitor of GABA amino transferase
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Question 98 of 107
This amine neurotransmitter is found in high concentration in cell bodies in the pons and brainstem; at some sites, release of the transmitter is autoregulated via presynaptic inhibition.
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Question 99 of 107
A young woman with bipolar disorder is pregnant. Which drug is safest for mood stabilization?
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Question 100 of 107
A 72-year old woman with a long history of anxiety that has been treated with diazepam decides to triple her daily dose. Two days after her attempts at self-prescribing, she is found extremely lethargic and non-responsive. Respiration is 8/min and shallow. Which of the following drugs should we give to reverse these signs and symptoms?
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Question 101 of 107
Progesterone is added to estrogens in hormone replacement therapy (HRT) to achieve which ALL of the following effects EXCEPT:
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Question 102 of 107
An 8 year old obese girl, diagnosed with Type 1 diabetes. The child will have to start taking insulin injections and not oral drugs because:
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Question 103 of 107
Select the drug which is neither analgesic, nor anti-inflammatory nor uricosuric, but is highly efficacious in acute gout
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Question 104 of 107
A 62-year-old woman with mild MS has some mild difficulty with walking. She is interested in becoming more active with walking and is considering walking a 3.1-mile event with her daughter. Which of the following agents may be beneficial in assisting her with improved ambulation?
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Question 105 of 107
A 42-year-old alcoholic man presents with confusion, ataxia, and ophthalmoplegia. The immediate treatment is
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Question 106 of 107
Which of the following statements is correct about buspirone?
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Question 107 of 107
Which of the following is the fastest acting anticoagulant?
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