A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked) and increased hair growth. Which of the following is most likely to produce the effects that your friend has described?
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Question 2 of 106
The antimuscarinic agent preferred in the management of motion sickness is
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Question 3 of 106
Noradrenaline is administered by
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Question 4 of 106
A floor nurse pages you about a patient who is having a chest pain. You order an electro-cardiogram and rush to see the patient. He describes the pain as tight pressure and is demonstrably sweating and gasping for air. The ECG comes back with acute ST-segment elevations in inferior leads, and you diagnose a myocardial infarction. You start giving the patient oxygen and give him sublingual nitro-glycerin and morphine for pain. You also give him another medication, which you have read may prolong his survival in this situation. What class of medication is it?
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Question 5 of 106
Verapamil is a drug used for treating hypertension. It should be used with caution with other drugs that can depress heart rate or contractility. Which drug, if given with verapamil, might therefore cause the greatest risk of depressing heart rate, contractile force or impulse conduction?
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Question 6 of 106
Which of the following drugs most likely caused the patient's symptoms of abnormal growth of the breast?
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Question 7 of 106
All of the following drugs are parasympatholytic drugs EXCEPT:
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Question 8 of 106
In relation to amphetamine all are true EXCEPT:
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Question 9 of 106
Neuromuscular blocking drugs do not produce central actions because
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Question 10 of 106
A 32-year-old woman was brought to the emergency department because of a generalized tonic-clonic seizure. Her husband stated that his wife had been suffering from epilepsy since childhood, but the seizures were only partially controlled by medication. Which of the following pairs of neurotransmitters are thought to be most involved in seizure disorders?
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Question 11 of 106
Which of the following muscle relaxants would be contraindicated in a patient with Tubocurarine deficiency of plasma cholinesterase?
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Question 12 of 106
Which of the following drugs would be contraindicated for inclusion in his anesthetic protocol?
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Question 13 of 106
Concurrent use of atropine will interfere with the anti-glaucoma action of
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Question 14 of 106
Which of the following drugs was most likely administered to facilitate avoidance from ethanol dependence?
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Question 15 of 106
Each of the following parasympathomimetics is paired with an appropriate therapeutic use EXCEPT:
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Question 16 of 106
Action of norepinephrine and epinephrine are terminated by
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Question 17 of 106
Which of the following descriptions best fits the drug phenylephrine?
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Question 18 of 106
Which of the following drugs most likely caused the patient's signs and symptoms?
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Question 19 of 106
Atropine is antagonist to which type of muscarinic
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Question 20 of 106
Following is a tertiary amine anti-muscarinic drug used for Parkinson's disease
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Question 21 of 106
In a patient given a cardiac glycoside, important effects of the drug on the heart include which of the following?
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Question 22 of 106
Withdrawal from which of the following drugs may have caused these symptoms?
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Question 23 of 106
Which of the following drugs most likely caused the patient's high blood pressure?
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Question 24 of 106
What is the primary role of acetylcholine in the nervous system?
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Question 25 of 106
Which of the following molecular actions most likely mediated the therapeutic effect of botulinum toxin in the patient's disorder?
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Question 26 of 106
There are two simple ways to lower blood pressure: (1) reduce the cardiac contractility, and (2) inhibit sympathetic-mediated vasoconstriction. Which one of the following drugs can lower blood pressure by both mechanisms?
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Question 27 of 106
Which of the following opioids did the patient most likely take?
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Question 28 of 106
Alpha methyl dopa can produce:
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Question 29 of 106
Which of the drugs would be most appropriate for this boy?
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Question 30 of 106
The action of ganglion blockers on the following items is essentially similar to atropine EXCEPT on:
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Question 31 of 106
Which of the following drugs most likely caused the patient's nausea?
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Question 32 of 106
Which of the following is approved for the treatment of hemorrhagic stroke?
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Question 33 of 106
Hyoscine differs from atropine in that it
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Question 34 of 106
Oxytremorine is a selective agonist of muscarinic receptors
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Question 35 of 106
Which of the following was most likely the primary reason for the use of cisatracurium instead of tubocurarine in this patient?
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Question 36 of 106
Which of the following organs is innervated only by parasympathetic nerves?
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Question 37 of 106
Match the nerves on the left to their target of innervation from the drop list on the right:
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Question 38 of 106
Which of the following opioids would be contraindicated in the patient with acute myocardial infarction?
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Question 39 of 106
Anti-cholinesterase drugs include the following drugs EXCEPT:
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Question 40 of 106
X is drug that contains a mixture of amphetamines. It is used for managing Attention-Deficit/Hyperactivity disorder (ADHD). The drug causes autonomic effects that can be fatal if an overdose is taken. How does X work in the body?
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Question 41 of 106
Pseudo-cholinesterase is present in
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Question 42 of 106
All the cholinomimetic alkaloids except one which is a choline ester
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Question 43 of 106
Which of the following is the drug of choice in treating suicidal overdose of digitoxin?
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Question 44 of 106
You are resident in a hospital in a very poor part of the world. Their drug selection is limited. A patient presents with acute cardiac failure, for which your preferred drug is dobutamine, given intravenously. However, there is none available. Which of the following other drugs, or combination of drugs, would be a suitable alternative?
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Question 45 of 106
Which of the following local anesthetics would be most appropriate for a pregnant woman with a history of anaphylactic reaction to para-aminobenzoic acid (PABA)?
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Question 46 of 106
Catecholamine D methyl transferase is found in all except
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Question 47 of 106
In a patient of myocardial infarction, ßadrenergic blockers are used with the following aim/aims:
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Question 48 of 106
The autonomic nervous system is also known as
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Question 49 of 106
Which of the following pairs of drugs would be most appropriate as a therapeutic regimen for the 37-year-old woman with acute psychotic state and history of seizures?
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Question 50 of 106
Which of the following drugs was most likely administered to achieve muscle relaxation in the 74-year-old man with impaired hepatic and renal function undergoing abdominal surgery?
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Question 51 of 106
Which of the following was most likely a site of this anorectic action of amphetamines?
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Question 52 of 106
Your patient is to receive a selective ß2 stimulant drug ß2 selective stimulant are often effective in
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Question 53 of 106
Which statement regarding the lacrimal gland is correct:
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Question 54 of 106
Which of the following ß-adrenoceptor blocker is the least lipid soluble?
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Question 55 of 106
Propranolol can produce the following EXCEPT:
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Question 56 of 106
What is the most appropriate treatment for a 15-month-old boy with repeated episodes of powerful contractions of trunk and limb muscles?
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Question 57 of 106
Accepted therapeutic indications for the use of antimuscarinic drugs include all of the following except
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Question 58 of 106
Which of the following drugs most likely caused the patient's death?
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Question 59 of 106
43-year-old woman with diagnosed myasthenia gravis presents with profound skeletal muscle weakness. We are unsure whether she is experiencing a cholinergic crisis or a myasthenic crisis, so we administer a usually appropriate dose of parenteral edrophonium. Assume the patient was actually experiencing a cholinergic crisis. Which of the following is the most likely response to the drug?
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Question 60 of 106
What is the primary mechanism of action of beta blockers?
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Question 61 of 106
Select the correct statement in relation to drug therapy of migraine
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Question 62 of 106
Which of the following pairs of drugs was most likely administered?
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Question 63 of 106
If farmers exposed to 'insecticides' ('irreversible' cholinesterase inhibitors) are given medical kits that contain atropine. Which one of the following effects of the cholinesterase inhibitor will NOT be blocked by the atropine?
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Question 64 of 106
Which of the following drugs did the patient most likely take?
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Question 65 of 106
The antibiotic that may accentuate the neuromuscular blockade produced by d-tubocurarine is
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Question 66 of 106
Which of the following is an orally active drug that blocks sodium channels and decreases action potential duration?
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Question 67 of 106
Monoamine oxidase enzyme (MAO) is responsible for:
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Question 68 of 106
Choose the correct statement from the following about α1- adrenergic receptor agonists
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Question 69 of 106
Which of the following items best explains the short action of diazepam in inducing unconsciousness for a laparoscopic hernia repair?
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Question 70 of 106
Vasoconstrictors should not be used in
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Question 71 of 106
Characteristics of Vitamin D and its metabolites include which one of the following?
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Question 72 of 106
Which of the following actions most likely mediated the reduction in the patient's tremor?
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Question 73 of 106
Which of the following drugs would be most appropriate for the 49-year-old woman complaining of difficulty sleeping?
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Question 74 of 106
We have a 48-year-old female patient with a history of myasthenia gravis. She has been treated with an oral acetyl cholinesterase inhibitor for several years, and has done well till now. She presents with muscle weakness and other signs and symptoms that could reflect either a cholinergic crisis (excess dosages of her maintenance drug) or a myasthenic crisis (insufficient treatment). We will use a rapidly acting parenteral acetyl cholinesterase inhibitor (AChE) to help make the differential diagnosis. Which of the following drugs would be most appropriate for this use?
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Question 75 of 106
A 39-year-old man diagnosed with tonic-clonic seizures 2 years ago had been receiving a drug that exhibits dose-dependent elimination kinetics. Which of the following drugs did the patient most likely take?
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Question 76 of 106
Which of the following muscle relaxants can be used to control spasticity associated with upper motor neurone paralysis ?
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Question 77 of 106
Which of the following agents is a prodrug that is much less toxic in mammals than in insects?
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Question 78 of 106
Salbutamol is used to treat:
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Question 79 of 106
Side effect which is observed only with the use of ßblockers and not with other sympathetic blocking agents
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Question 80 of 106
Non-selective ß-blockers are contraindicated in:
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Question 81 of 106
Which mm. are innervated by n. facialis:
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Question 82 of 106
A 3-year-old boy was brought to the emergency department. Which of the following ion channels does activation of GABA receptors in the brain and spinal cord most likely open?
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Question 83 of 106
The neurotransmitter released at the end of most sympathetic nerve fibers is:
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Question 84 of 106
The following sympathomimetic drug is a catecholamine:
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Question 85 of 106
What is the primary effect of alpha-1 receptor activation?
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Question 86 of 106
Which of the following adverse effects is most likely to occur during the first days of lithium therapy?
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Question 87 of 106
Which drug was most likely prescribed for the 45-year-old man with simple partial seizure who was already on lamotrigine and needed additional therapy to decrease the frequency of attacks?
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Question 88 of 106
Which of the following drugs was most likely prescribed for the 12-year-old boy with irritability and self-injurious behavior?
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Question 89 of 106
Which of the following drugs most likely caused the symptom reported by the patient?
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Question 90 of 106
Atropine in doses of 2.0 mg to 5.0 mg may cause
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Question 91 of 106
Concerning catecholamines all the following are true EXCEPT:
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Question 92 of 106
The parasympathetic nervous system is most active during:
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Question 93 of 106
Each of the following types of receptors is correctly matched with the response resulting from its stimulation EXCEPT:
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Question 94 of 106
Nitroglycerin, either directly or through reflexes, results in which one of the following effects
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Question 95 of 106
The most effective antidote for belladonna poisoning is
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Question 96 of 106
A drug with which of the following molecular mechanisms of action would be appropriate for this patient?
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Question 97 of 106
The thoracic spinal nerves are:
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Question 98 of 106
Atropine:
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Question 99 of 106
ß-blockers are contraindicated in
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Question 100 of 106
Which of the following is not a therapeutic use of adrenaline:
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Question 101 of 106
A short acting cycloplegic and mydriatic drug is:
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Question 102 of 106
Atropine has the following pharmacological effects EXCEPT:
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Question 103 of 106
Which of the following drugs most likely interacted with metoclopramide, thus triggering the adverse effects reported by the patient?
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Question 104 of 106
Which of the following drugs was most likely administered?
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Question 105 of 106
A man has been searching for an aphrodisiac or some other agent to enhance 'sexual performance' discovers yohimbine. He consumes the drug in excess and develops symptoms of toxicity that require your intervention. Which of the following should you expect as a response to this drug?
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Question 106 of 106
The ß-adrenergic blocker which possesses both ß1 selectivity as well as intrinsic sympathomimetic activity is
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