Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because
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Question 2 of 105
A 43-year-old man who is a heroin addict is placed on methadone therapy to wean him off of heroin. Which of the following statements is true regarding the pharmacology of this agent?
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Question 3 of 105
The inhalation anesthetic with the fastest onset of action is
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Question 4 of 105
Which one of the following chemicals does not satisfy the criteria for a neurotransmitter role in the CNS?
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Question 5 of 105
Dale's vasomotor reversal phenomenon is exhibited by
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Question 6 of 105
Which of the following is a high-potency antipsychotic drug having minimal sedative and autonomic effects and no propensity to cause weight gain?
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Question 7 of 105
A 35-year-old man who is an immigrant has been taking prazepam for anxiety for 10 years. This drug is not available in the United States, so he goes to see a physician about a drug that would be a good replacement. What might happen to this patient if he was unable to replace his prazepam and abruptly quit taking it?
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Question 8 of 105
A 58-year-old woman with a history of myasthenia gravis presents to the emergency department complaining of generalized abdominal pain. Her current medications include nifedipine and neostigmine. Her caretaker reports that her bottle of neostigmine is empty but was full earlier in the day. Which of the following findings is likely in this patient?
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Question 9 of 105
Patients taking chronic doses of non-selective NSAIDs should be periodically screened for which toxicities?
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Question 10 of 105
IV administration of phenytoin in status epilepticus carries the danger of
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Question 11 of 105
Which of the following factors indicates that withdrawal of the successfully used antiepileptic medication is likely to result in recurrence of seizures?
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Question 12 of 105
Flumazenil
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Question 13 of 105
Which of the following describes the usual course of rheumatoid arthritis?
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Question 14 of 105
As the physician who is prescribing levodopa, you will note that the drug
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Question 15 of 105
For induction of anaesthesia, nitrous oxide is superior to ether because
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Question 16 of 105
An unconscious patient is brought to the emergency department with a history of an unknown drug overdose. Which of the following actions should the physician perform?
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Question 17 of 105
The following is a selective serotonin reuptake inhibitor used in treatment of psychic depression:
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Question 18 of 105
Which one of the following drugs may increase anticoagulant effects by displacement of warfarin from plasma protein binding sites and is inactive until converted in the body to an active metabolite?
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Question 19 of 105
Persistent dry cough may occur as a side effect of the following antihypertensive drug
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Question 20 of 105
Potassium-sparing diuretics should not be coadministered with
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Question 21 of 105
Regarding local anaesthetics (LA), which statement is true?
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Question 22 of 105
A 55-year-old woman undergoes surgery. She receives several drugs for preoperative care and intraoperative. Toward the end of the procedure she develops hyperthermia, hypertension, hyperkalemia, muscle rigidity, and metabolic acidosis. Which of the following drugs is most likely to have participated in this reaction?
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Question 23 of 105
Which of the following benzodiazepines is expected to cause the least amount of adverse effects in the elderly?
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Question 24 of 105
A child requires multiple minor surgical procedures in the nasopharynx. Which of the following drugs has high surface activity and vasoconstrictor actions that reduce bleeding in mucous membrane?
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Question 25 of 105
Propylthiouracil can produce:
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Question 26 of 105
Regarding the cardiac and therapeutic effect of phenytoin, which of the following is true?
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Question 27 of 105
For a patient with peptic ulcer, the safest nonopioid analgesic is
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Question 28 of 105
Side effects of benzodiazepines include the following EXCEPT:
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Question 29 of 105
The mechanism by which thiocyanate reduces synthesis of thyroid hormones is by inhibition of which of the following?
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Question 30 of 105
For patients who have been on long-term therapy with a glucocorticoid and who now wish to discontinue the drug, gradual tapering of the glucocorticoid is needed to allow recovery of:
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Question 31 of 105
The unique property of SERMs is that they:
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Question 32 of 105
Probenecid increases the excretion of
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Question 33 of 105
General anaesthesia for surgery requires
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Question 34 of 105
Following is an inverse agonist of benzodiazepine receptors
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Question 35 of 105
Prostaglandins involved in inflammatory processes are produced from arachidonic acid by
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Question 36 of 105
An opioid analgesic is preferred over aspirin-like analgesics in
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Question 37 of 105
Which of the following drugs acts as a competitive benzodiazepine receptor antagonist:
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Question 38 of 105
The distinctive feature of the isoenzyme cyclooxygenase-2 is
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Question 39 of 105
Following gold compound is generally administered orally
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Question 40 of 105
The primary objective for designing drugs that selectively inhibit COX-2 is to
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Question 41 of 105
In hypothyroidism, T4 is more commonly prescribed as a supplement than T3 because:
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Question 42 of 105
Which of the benzodiazepines is used only as a sedative and hypnotic
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Question 43 of 105
A 72-year-old woman with Parkinson's disease is taking a medication that increases release of dopamine, blockade of cholinergic receptors, and inhibiting the N-methyl-D-aspartate receptor. This describes which of the following agents?
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Question 44 of 105
A 64-year-old man presents with a shuffling gait, cogwheel rigidity, and a resting tremor. His physician prescribes levodopa and his symptoms greatly improve, supporting a diagnosis of Parkinson's disease. How does levodopa help this patient's symptoms?
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Question 45 of 105
Which of the following is the most common adverse effect of metformin?
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Question 46 of 105
Epinephrine is often included in local anesthetics because it
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Question 47 of 105
Alcohol drinking is associated with which of the following changes in serum lipid concentrations?
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Question 48 of 105
Which of the following neuromuscular blocking agents can cause muscarinic responses such as bradycardia and increased glandular secretions?
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Question 49 of 105
The H1 receptor antagonist with high anticholinergic activity is
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Question 50 of 105
In review of the benzodiazepine class, which of the following agents has the longest duration of action and may be useful in the treatment of a 39-year-old patient with spinal cord injury and with skeletal muscle spasticity?
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Question 51 of 105
Which of the following drugs displaces plasma protein-bound phenytoin as well as decreases its metabolism
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Question 52 of 105
A patient with severe schizophrenia started therapy with clozapine. Which of the following is the most serious adverse response associated with this drug?
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Question 53 of 105
A 35-year-old female who has never been pregnant suffers each month from pain, discomfort, and mood depression at the time of menses. She may benefit from the use of this selective inhibitor of the reuptake of serotonin.
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Question 54 of 105
Which of the following drugs is claimed to have a therapeutic effect in senile dementia and has adrenergic blocking activity?
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Question 55 of 105
Minipill hormonal contraception is composed of:
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Question 56 of 105
Aspirin has all the following effects EXCEPT:
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Question 57 of 105
Prolonged painful erection of penis has been noted particularly as a side effect of
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Question 58 of 105
A 43-year-old woman with a history of fibromyalgia and depression presents to her primary care physician for treatment. She complains of feeling sad and worthless in addition to multiple somatic complaints. Which of the following treatments would be best for this patient?
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Question 59 of 105
Aspirin is used in treatment of:
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Question 60 of 105
A 47-year-old man with seizure disorder presents to his primary care physician for follow-up. Because of a recent exacerbation in his seizures, he is prescribed with lacosamide. Which of the following is the most likely mechanism of action of this medication?
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Question 61 of 105
Spinal anesthesia is not suitable for
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Question 62 of 105
The following opiate drugs are paired correctly with their pharmacological class, EXCEPT:
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Question 63 of 105
The D3 receptors are preferentially present in
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Question 64 of 105
The tricyclic antidepressant drugs produce their effect by
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Question 65 of 105
Some NSAIDs may reduce inflammation by
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Question 66 of 105
Blood pressure is thought to generally remain unchanged with which one of the following anaesthetic agent
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Question 67 of 105
Bisphosphonates are indicated in the following condition
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Question 68 of 105
The following prostanoid is a potent inducer of platelet aggregation
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Question 69 of 105
A local anaesthetic in its lowest concentration will block
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Question 70 of 105
A 67-year-old man with hypertension is treated with guanethidine. He has been taking this medication for years. His blood pressure is 130/86 mm Hg. Which of the following adverse effects must this patient be aware of?
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Question 71 of 105
A 66-year-old woman who has smoked two packs of cigarettes per day for 50 years has chronic bronchitis. She has tried to quit five times in the past but felt she could not go long without a cigarette. The nicotine in her cigarettes stimulates many cells in her body by binding certain receptors. Which of the following drugs blocks nicotinic receptors?
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Question 72 of 105
The anticholinergic used only as preanesthetic medication is
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Question 73 of 105
A patient of CHF was treated with furosemide and digoxin. He became symptom-free and is stable for 3 months. What is the next step?
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Question 74 of 105
Which of the following group of analgesic drugs act on the CNS?
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Question 75 of 105
Plasma lithium levels may become toxic in the presence of all of the following EXCEPT
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Question 76 of 105
A 45-year-old man with attention-deficit/hyperactivity disorder presents to his primary care physician for evaluation and treatment. Physical examination of the heart, lungs, and abdomen are within normal limits. The patient has begun on atomoxetine. Which of the following underlying disorders must the treating physician be aware of?
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Question 77 of 105
Corticosteroids exert anti-inflammatory action by inhibiting the following enzyme
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Question 78 of 105
Which bone is affected more by glucocorticoid-induced osteoporosis?
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Question 79 of 105
Pilocarpine reduces intraocular tension in open-angle glaucoma by
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Question 80 of 105
Though ethacrynic acid is also a high-ceiling diuretic, it is rarely used compared to furosemide because
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Question 81 of 105
A glycine antagonist is
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Question 82 of 105
Which one of the following processes plays the major role in terminating the action of phenobarbitone
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Question 83 of 105
Recreational use of drugs sometimes leads to dependence. Which of the following is least likely to cause physical dependence?
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Question 84 of 105
Sensitivity of a nerve fiber to blockade by lidocaine depends on
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Question 85 of 105
The following antihypertensive drug tends to lower plasma renin activity
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Question 86 of 105
Established clinical uses of this drug include enuresis and chronic pain
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Question 87 of 105
What is true of methylphenidate?
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Question 88 of 105
The following statements are correct about MAO inhibitors EXCEPT:
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Question 89 of 105
A group of teenage boys comes to the emergency department after ingesting a plant they heard would make them high. One member of the group still had some plant parts in his pocket, which you use to identify deadly nightshade that contains compounds metabolized to atropine. Which of the following is an effect of atropine?
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Question 90 of 105
When an amide is acted upon by an amidase
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Question 91 of 105
The diuretic of choice for the initial treatment of a patient with either acute or chronic renal failure (ARF, CRF) whose creatinine clearance is below 25 ml/min is
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Question 92 of 105
Cigarette smoking increases the side effects of
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Question 93 of 105
Regarding opioid receptors, which statement is true?
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Question 94 of 105
In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine?
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Question 95 of 105
Probenecid is effective in the treatment of gout because it:
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Question 96 of 105
A 5-year-old child is admitted to the hospital with low grade fever and a persistent cough. His throat culture is negative, his fever has resolved, and all that is left is slight cough. Which of the following is an OTC opioid antitussive could the paediatrician recommend for this child?
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Question 97 of 105
Quinidine is contraindicated in
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Question 98 of 105
Which of the following is an ergot derivative used in Parkinson's disease as a dopamine agonist?
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Question 99 of 105
Possible treatment of hypoglycemia should NOT include:
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Question 100 of 105
Narcotic analgesics include which of the following:
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Question 101 of 105
Ultrashort duration of effect of thiopentone sodium given intravenously is due to
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Question 102 of 105
The triad of coma, pinpoint pupil and decreased respiration points toward poisoning with
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Question 103 of 105
Mental retardation, microcephaly, and underdevelopment of the midface region in an infant is associated with chronic maternal abuse of
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Question 104 of 105
Nonsteroidal anti-inflammatory drugs reduce the diuretic action of furosemide by
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Question 105 of 105
A 30-year-old male patient is on drug therapy for a psychiatric problem. He complains that he feels ‘flat' and confused at times, has gained weight, lost his sex drive, and experiences tremors. He also has excessive thirst and frequent urination. The drug he is most likely to be taking is
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