Primary immunodeficiency producing susceptibility to infection by viruses and molds is due to?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 2 of 60
A 7-year-old child presented with severe stridor and abdominal pain, he gives history of recurrent episodes of nonpruritic edema lasting 48 to 72 hours, which usually triggered by stress, or anxiety. Of the following, the MOST likely cause is deficiency of
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 3 of 60
Which of the following provides antiviral state to cells
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 4 of 60
Natural killer cells
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 5 of 60
Neutropenia (for white children 1 year of age or older) is defined as an absolute neutrophil count (ANC) less than
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 6 of 60
In heterozygous individuals who have, for example, inherited two alternative forms of the constant region gene for IgG1 (i.e., IgG1m(1) and IgG1m(2)), which of the following is true regarding the Ig expression by a particular B cell, according to allelic exclusion?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 7 of 60
Mast cell arachidonic acid metabolites include cyclo-oxygenase, which produces prostaglandins that stimulate and increase of smooth muscle in the gut and bronchi. Metabolites also include leukotrienes, which have a effect than prostaglandins.
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 8 of 60
Approximately how many cells survive the selection process?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 9 of 60
In the classical complement pathway, which of the following components is the initiating protein(s)?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 10 of 60
Which of the following is not true of monocytes and neutrophils?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 11 of 60
Which of the following molecules triggers the caspase cascade And through which cells
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 12 of 60
A male infant presents with decreased levels of IgA, IgG, and IgE. History reveals recurrent bacterial infections and severe diarrhea. A mutation on CD40L (CD154) on T cells is suspected. Which of the following is the most likely?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 13 of 60
Wrong about Macrophages
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 14 of 60
A child is scratched by a bat. Because of the risk of rabies, the child is immediately given human rabies immune globulin. This is an example of which of the following?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 15 of 60
A young child undergoes implantation of a cardiac pacemaker. During surgery, the physician must remove the thymus. If this child encounters an antigen requiring B-cell-Tcell collaboration, they will to mount an immune response. These antigens are thus called
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 16 of 60
Which of the following components of the innate immune system involves the release of histamine?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 17 of 60
A cell found in the circulation that secretes INF α and INF β is a
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 18 of 60
Plasma cells are the end cells of
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 19 of 60
Reported complications of intravenous immunoglobulin therapy include all of the following EXCEPT
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 20 of 60
The following conditions can cause eosinophilia EXCEPT
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 21 of 60
Which of the following is a low affinity antibody?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 22 of 60
Low pH
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 23 of 60
A male patient presents with severe and recurrent bacterial infections. Lab work confirms the patient is only infected with certain bacteria due to a mutation in a gene for NADPH oxidase. Which of the following is the most likely?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 24 of 60
Antigens and lymphoid cells are delivered to the secondary lymphoid tissues (spleen, lymph nodes) via:
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 25 of 60
Activation of the complement system directly causes?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 26 of 60
Co-receptor molecule involved in signal transduction
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 27 of 60
All of the following are associated with chronic granulomatous disease (CGD) EXCEPT
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 28 of 60
A 40-day-old, previously healthy, fullterm female infant manifests fever, lethargy, and poor feeding for 12 hours. Physical examination reveals a lethargic child with vital signs of RR 70, HR 185, BP mean 25, T 39.50°C. The peripheral perfusion is poor, the chest reveals retractions, the abdomen is soft and reveals persistence of the umbilical cord, and the extremities are cool. Laboratory studies reveal a white blood cell count of 65,000 and a platelet count of 105,000. Family history reveals that a male sibling died suddenly at the age of 2 months, 10 years prior to the birth of this child. The most likely diagnosis is
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 29 of 60
Pathogens can evade the immune system through antigenic drift, which is a mutation that leaves existing antibodies and antigenic shift, which is a mutation that leaves existing antibodies
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 30 of 60
The thymus is the primary site of T-cell development. Which of the following is the correct order arranged from the area with the earliest progenitor cells to the area with the most mature T lymphocytes?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 31 of 60
What stage of an adaptive immune response involves secretion of antibody from a large plasma cell with extensive endoplasmic reticulum?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 32 of 60
In chronic granulomatous disease (CGD), the best method to detect and follow up deep-seated infection is
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 33 of 60
A 13-month-old girl presented with failure to thrive, repeated chest infection, and fatty offensive diarrhea. Hemoglobin level 8.8 gm/dl, platelate count 150/mm3, white blood cell count 3.500/mm3, with absolute neutrophil count (ANC) 500/μL. Of the following, the MOST likely diagnosis is
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 34 of 60
Vaccines (natural exposure) is considered active immunotherapy and leads to the development of immunologic memory.
The difference between tolerance and immunity depends upon the maturation status of the antigen presenting dendritic cells. What is the T-cell outcome of an antigen presentation event by a mature dendritic cell?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 39 of 60
Presence of the TCR co-receptor molecules (CD4 or CD8) has been estimated to reduce the number of MHC-peptide complexes required to trigger a T-cell response by about:
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 40 of 60
During B cell development, when is there rearrangement in the light (L) chain of the immunoblobulin gene started?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 41 of 60
Choose the best answer. Rheumatoid arthritis is a/an...?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 42 of 60
Pus formed at the site of infection is largely composed of dead:
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 43 of 60
The process used to increase antigen binding affinity is called somatic and occurs in cells but not cells.
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 44 of 60
Which of the following is a large genomic region or gene family found in most vertebrates, playing an important role in immunity?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 45 of 60
Insulin-dependent diabetes mellitus
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 46 of 60
which of the following initiates the classical pathway of the complement system
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 47 of 60
The person in the above question is experiencing a primary infection with the virus. B cells activated in a primary infection secrete which class of antibody first?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 48 of 60
MHC class I has peptides of amino acid residues and is an antigen. MHC class II has peptides of amino acid residues and is an antigen.
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 49 of 60
A 2-year-old boy presented with failure to thrive, neonatal hypocalcemic seizure, and three attacks of sepsis. Examination reveals cleft palate and holo-systolic murmur. Of the following, the genetic predisposition of this condition is
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 50 of 60
Which of the following is a very sensitive and simple test for antigens, which uses a covalent complex of enzyme linked to antibody, to detect antigen directly or to bind antibody-antigen complex?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 51 of 60
Which of the following is NOT true regarding effective immunogens?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 52 of 60
The genes encoding which of the following can undergo hypermutation to create receptors that are an even better fit for foreign antigens?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 53 of 60
Pepsin cleaves what region of immunoglobulin?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 54 of 60
Which of the following alerts the adaptive immune system to the presence of infection?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 55 of 60
Major source of antigen-specific protection against viral infection
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 56 of 60
Certain strains of adenovirus express a protein that inhibits the transcription of class I MHC molecules. What is a consequence of this?
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 57 of 60
Intraepithelial lymphocytes (IEL) act to protect the host against viral and bacterial pathogens encountered in the gut and secrete cytokines. Their predominant phenotype is:
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 58 of 60
During the development of B cells, the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination). The complex of enzymes involved in somatic recombination in lymphocytes is called:
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 59 of 60
Binds antigen
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
ATI RN · Pediatric Immunization Test Questions
Question 60 of 60
BCG is used to protect against
Select an option. Use Strike to cross one out.
Rationale
Did you know the question?
End of free preview
You have finished the first five questions. Sign in to continue this set and save your progress.
