Pediatric Immunization Practice Questions

ATI RN · Pediatric Immunization Practice Questions

Question 1 of 57

Makes integrins more 'sticky'

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ATI RN · Pediatric Immunization Practice Questions

Question 2 of 57

The interaction of which molecule on the membrane of cells with its ligand signals apoptosis?

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ATI RN · Pediatric Immunization Practice Questions

Question 3 of 57

Lymphocyte passage (diapedesis or transmigration) occurs at the between adjacent endothelial cells then into the tissues.

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ATI RN · Pediatric Immunization Practice Questions

Question 4 of 57

The adaptive immune system develops from stem cells originating in the

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ATI RN · Pediatric Immunization Practice Questions

Question 5 of 57

Matching: Immunodeficiency - Most severe of congenital immunodeficiencies

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ATI RN · Pediatric Immunization Practice Questions

Question 6 of 57

Allelic exclusion creates monospecific B-cell receptors (BCRs). The result is these cells each secrete:

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ATI RN · Pediatric Immunization Practice Questions

Question 7 of 57

Class II MHC molecules accommodate peptides and thus be referred to analogously as a 'hotdog in a bun', in contrast to class I MHC molecules.

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ATI RN · Pediatric Immunization Practice Questions

Question 8 of 57

The mutation on the X chromosome responsible for X-SCID is in the gene for a subunit of several cytokine receptors. Which of the following is true for boys affected with X-SCID at birth?

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ATI RN · Pediatric Immunization Practice Questions

Question 9 of 57

Secrete cytokines if damaged

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ATI RN · Pediatric Immunization Practice Questions

Question 10 of 57

Paracortex

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ATI RN · Pediatric Immunization Practice Questions

Question 11 of 57

Which of the following key components of the complement pathway can be activated by the lectin, classical, and alternative pathways?

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ATI RN · Pediatric Immunization Practice Questions

Question 12 of 57

Natural killer cells are thought to fill the gap between initial innate response and adaptive immune response. They evolved to detect low levels of MHC caused by the diseases of and

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ATI RN · Pediatric Immunization Practice Questions

Question 13 of 57

In the processing pathway for extracellular antigens, synthesis of MHC class II and invariant chain (li) occurs in the

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ATI RN · Pediatric Immunization Practice Questions

Question 14 of 57

Which of the following is chiefly found on the surface of B cells as a receptor molecule and is involved in cell activation?

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ATI RN · Pediatric Immunization Practice Questions

Question 15 of 57

The deficiency of the complement component factor D and properdin lead to the recurrent bacterial infection. Which of the following pathway is affected in this condition?

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ATI RN · Pediatric Immunization Practice Questions

Question 16 of 57

Which of the following clear Viral infected cells that doesn't exhibit MHC-1

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ATI RN · Pediatric Immunization Practice Questions

Question 17 of 57

Wrong about antigen interaction with lymphocytes

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ATI RN · Pediatric Immunization Practice Questions

Question 18 of 57

Superantigens such as staphylococcal enterotoxins bind to certain TCR chains and to MHC class II molecules. MHC binding does not involve the peptide groove. T cells can then release extremely high levels of cytokines, which lead to toxic shock syndrome (TSS) when they appear in the blood.

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ATI RN · Pediatric Immunization Practice Questions

Question 19 of 57

Mature naive B cells...?

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ATI RN · Pediatric Immunization Practice Questions

Question 20 of 57

A 13-month-old male presented with vomiting, fever, and irritability. On examination his temperature was 40Ã‚Â°C, lethargic, with atrophied tonsils, clear tympanic membrane, clear chest and neck stiffness. The parents gave past history of pneumonia at the age of 6 and 9 months for which he was admitted to hospital and treated with i.v. antibiotics for 10 days. Of the following, the MOST likely diagnosis is

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ATI RN · Pediatric Immunization Practice Questions

Question 21 of 57

Class switching (isotype switching) involves rearrangement of the V(H) exon to associate with a different C(H) exon at different times in the course of an immune response. The region of the antibody molecule is affected (changed) via class switching and, unlike somatic recombination, this process is antigen

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ATI RN · Pediatric Immunization Practice Questions

Question 22 of 57

The immune system uses as well as molecules (e.g. complement components). The immune system uses as well as antigen recognition molecules.

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ATI RN · Pediatric Immunization Practice Questions

Question 23 of 57

What is the immunologic consequence of mutation in CD40L (CD154)?

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ATI RN · Pediatric Immunization Practice Questions

Question 24 of 57

Which of the following best describes the location of the delta (Î´)-chain locus in human T-cell receptors?

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ATI RN · Pediatric Immunization Practice Questions

Question 25 of 57

How many binding sites there are between Complementarity Determining Regions (CDR) and an antigen on one Fab

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ATI RN · Pediatric Immunization Practice Questions

Question 26 of 57

Humoral immunity is mediated by antibodies from and is involved in the elimination of pathogens. Cell mediated immunity is mediated by and is involved in the elimination of pathogens.

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ATI RN · Pediatric Immunization Practice Questions

Question 27 of 57

Macrophages serve as antigen presenting cells and activate

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ATI RN · Pediatric Immunization Practice Questions

Question 28 of 57

Regarding the structure of the T-cell receptor, which of the following is NOT an invariant CD3 protein chain?

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ATI RN · Pediatric Immunization Practice Questions

Question 29 of 57

Rhematoid arthritis

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ATI RN · Pediatric Immunization Practice Questions

Question 30 of 57

Opsonization is the process by which bacteria and other cells are made available for phagocytosis and involves opsonin or IgG. Which complement components is/are mainly involved?

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ATI RN · Pediatric Immunization Practice Questions

Question 31 of 57

Subunit vaccines contains components from pathogens, which are inactivated and referred to as These vaccines are generally of low immunogenicity and may need to work effectively.

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ATI RN · Pediatric Immunization Practice Questions

Question 32 of 57

An 18-month-old male child presented with failure to thrive and chronic diarrhea. On examination he has dermatitis, generalized lymphadenopathy, hepatosplenomegaly, and deep seated infection in the inguinal area. His lab. investigations revealed anemia and hypergammaglobulinemia. Of the following, the MOST likely diagnosis is

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ATI RN · Pediatric Immunization Practice Questions

Question 33 of 57

Digeorge syndrome is known to increase likelihood of infection of some microbes, why is that?

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ATI RN · Pediatric Immunization Practice Questions

Question 34 of 57

Which of the following is not associated with neutropenia?

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ATI RN · Pediatric Immunization Practice Questions

Question 35 of 57

A 4-year-old boy presented with high fever, decreased appetite, aphthous stomatitis, and cellulitis of the right calf muscle. His absolute neutrophil count (ANC) was 600/Î¼L. The MOST likely organisms causing this condition are

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ATI RN · Pediatric Immunization Practice Questions

Question 36 of 57

Which of the following are lineage restricted, morphologically identifiable, and express differentiation markers?

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ATI RN · Pediatric Immunization Practice Questions

Question 37 of 57

Which is the most common defined immunodeficiency disorder?

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ATI RN · Pediatric Immunization Practice Questions

Question 38 of 57

Activation of a T cell requires ___. Following activation, the T cell proliferates and differentiates into ___, then moves into peripheral tissues and other organs.

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ATI RN · Pediatric Immunization Practice Questions

Question 39 of 57

Which of the following uses the enzyme horseradish peroxidase (HRP)?

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ATI RN · Pediatric Immunization Practice Questions

Question 40 of 57

CD4 molecules bind with MHC molecules and are found on (expressed by) cells. CD8 molecules bind with MHC molecules and are found on (expressed by) cells.

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ATI RN · Pediatric Immunization Practice Questions

Question 41 of 57

The complement system plays a key role in the host defense process. Which of the following components of this system is the most important in chemotaxis?

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ATI RN · Pediatric Immunization Practice Questions

Question 42 of 57

A 17-month-old girl presented with history of recurrent attacks of pneumonia since the age of 8 months. You suspect a predominant B-cell defect. Of the following, the BEST simple initial screening test is

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ATI RN · Pediatric Immunization Practice Questions

Question 43 of 57

All the following are features of ataxia-telangiectasia EXCEPT

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ATI RN · Pediatric Immunization Practice Questions

Question 44 of 57

Which of the following produce large amounts of antibodies (Igs) and differentiate upon stimulation from CD4+ cells?

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ATI RN · Pediatric Immunization Practice Questions

Question 45 of 57

Parasitic worm eggs are resistant to low pH and proteolytic digestion in the stomach. Adult worms living inside the lower gut are protected from many of the components of the immune response. Mast cells respond to worms. What immunoglobulin activates these mast cells, leading to degranulation?

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ATI RN · Pediatric Immunization Practice Questions

Question 46 of 57

Activates the complement system

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ATI RN · Pediatric Immunization Practice Questions

Question 47 of 57

Matching: Complement deficiency - Lupus-like syndrome

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ATI RN · Pediatric Immunization Practice Questions

Question 48 of 57

In which of the following developmental stages of T cells are surface molecules CD4 and CD8 NOT expressed?

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ATI RN · Pediatric Immunization Practice Questions

Question 49 of 57

Adaptive immune system response typically takes how long?

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ATI RN · Pediatric Immunization Practice Questions

Question 50 of 57

Which cytokine is essential for T-cell proliferation and is also necessary for the production of CD25-positive regulatory T cells?

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ATI RN · Pediatric Immunization Practice Questions

Question 51 of 57

A patient in their early 20s presents with recurrent bacterial infections. Lab work shows B cells in the periphery as well as low immunoglobulin levels. History shows immunoglobulin levels have decreased with age. Which of the following is the most likely?

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ATI RN · Pediatric Immunization Practice Questions

Question 52 of 57

A patient presents for a follow-up visit after a diagnosis of systemic lupus erythematosus (SLE). The physician suspects a misdiagnosis after finding immune complexes accumulated in the blood, lymph, and tissues. Which of the following is the most likely?

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ATI RN · Pediatric Immunization Practice Questions

Question 53 of 57

In patient with ChÃ©diak-Higashi syndrome, the only curative therapy is hematopoietic stem cell transplantation which correct all the following EXCEPT

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ATI RN · Pediatric Immunization Practice Questions

Question 54 of 57

What fraction of serum are the antibodies (immunoglobulins) initially found when using lytical techniques (e.g. electrophoresis)?

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ATI RN · Pediatric Immunization Practice Questions

Question 55 of 57

A patient suffering from recurrent mucosal infections and celiac disease. Turns out he is affected with a primary immunodeficiency. He is most probably affected with...?

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ATI RN · Pediatric Immunization Practice Questions

Question 56 of 57

A graft between members of the same species is termed an?

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ATI RN · Pediatric Immunization Practice Questions

Question 57 of 57

Which of the following regulators inhibits C3convertase

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