Which complement pathway is activated by (and requires) antibodies, with IgM being particularly good at C1 binding?
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ATI RN · Pediatric Immunity NCLEX Questions
Question 2 of 60
Most peripheral B cells belong to a pool of long lived follicular B lymphocytes called ___ cells. The majority of B cells found in the fetus and neonate are ___ cells, which express the surface marker CD5. ___ cells are the most likely to be involved in autoimmunity.
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Question 3 of 60
Which of the following types of antigen presenting cells (APCs) is specialized for degradation and presentation of particulate antigens to T cells?
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Question 4 of 60
In the classical pathway, which of the following complement complex serve as C3 convertase
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Question 5 of 60
Shifting to the left (proportion of immature neutrophil cells >5%) may occasionally be caused by all the following EXCEPT
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Question 6 of 60
Follows concentration gradient of chemokines to the site of infection
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Question 7 of 60
Establishment of self-restriction occurs in the thymus and is called ___ selection. Establishment of central self-tolerance occurs in the thymus and is called ___ selection.
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Question 8 of 60
If a B cell successfully rearranges the first heavy chain locus, it inhibits the rearrangement of the other heavy chain on the other chromosome. What is this called?
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Question 9 of 60
Pathogen-associated molecular patterns
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Question 10 of 60
Which immune system cells recognize body cells with reduced expression of MHC class I molecules?
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Question 11 of 60
The first immunoglobulin heavy chain class to be expressed on the surface of a newly produced B-cell is...?
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Question 12 of 60
Which of the following would be used as preliminary screening for the presence of antibodies to HIV proteins in a patient's blood sample?
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Question 13 of 60
Which of the following is the main immunoglobulin in the gut and secretions (saliva, milk, tears) and is important in mucosal immunity?
T cells are made in the and complete their differentiation in the
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Question 16 of 60
Has an fragment crystallizable (Fc) and Fab region
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Question 17 of 60
Delayed separation of umbilical cord, absence of pus at site (s) of infection, and poor wound healing suggest
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Question 18 of 60
Regarding chemokines, which one of the following is the most accurate?
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Question 19 of 60
Mutations in the gammac chain of the receptors for IL-2, 4, 7, 9 and 15 lead to?
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Question 20 of 60
Delayed separation of the umbilical cord after birth suggests which type of immune dysfunction?
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Question 21 of 60
Which of the following diseases affects mature T cells?
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Question 22 of 60
Involved in signal transduction on different T cells
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Question 23 of 60
What types of cell is class II MHC found on?
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Question 24 of 60
Which of the following describes where class I MHC is found and not where class II MHC is found?
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Question 25 of 60
In addition to infection and bleeding, the MOST common cause of death in Wiskott-Aldrich syndrome is
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Question 26 of 60
A medical student acquired hepatitis B through a needle-stick injury. The student had not received their vaccinations for this virus and eventually experienced liver problems. One of the clinical signs of this disease is jaundice, which turns the skin and sclera what color?
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Question 27 of 60
are trafficked via cell adhesion molecules (CAMs), which are a part of the immunoglobulin superfamily.
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Question 28 of 60
Histamine releasing cell and contributes in hypersensitivity
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Question 29 of 60
A 6-month-old presents with recurrent cellulitis and bacteremias due to Staphylococcus aureus. The white blood cell count is 2500 with 5% neutrophils, 10% eosinophils, 35% monocytes, and 50% lymphocytes. The platelet count is 650,000. A brother and a female cousin died at the age of 18 months and 2 years, respectively. The most likely diagnosis is
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ATI RN · Pediatric Immunity NCLEX Questions
Question 30 of 60
Good pasture's syndrome
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Question 31 of 60
Cellular interactions between B and T cells involve costimulatory activation. There is a physical interaction between ___ on the B cell and ___ on the T cell. This leads to a B cell producing high affinity antibody.
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Question 32 of 60
Antigen presenting cells (APCs) include macrophages and dendritic cells, which are found in lymphoid tissues and the These are critical in the uptake and presentation of antigen to T cells.
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Question 33 of 60
Persons with helminth infections mount immunologic responses that involve IgE and eosinophils. Which two cytokines are most important for these responses to occur?
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Question 34 of 60
large family of molecules that stimulate leukocyte movement and regulate the migration of leukocytes from the blood to tissues and all of which are 8- to 12kD polypeptides, this definition best describes?
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Question 35 of 60
Which of the following best describes the role of the pre-B cell receptor (pre BCR)?
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Question 36 of 60
Which of the following tests is an effective screening for T-cell function?
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Question 37 of 60
The spleen responds to antigens and the lymph nodes respond to antigens for presentation to
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Question 38 of 60
Which of the following live vaccines is recommended for adults but not children?
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Question 39 of 60
Chronic neutropenia by definition lasts longer than
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Question 40 of 60
Monocytes move from the systemic circulatory system into general connective tissues, where they differentiate into what phagocytic cell type?
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Question 41 of 60
Produce antibody and express immunoglobulin
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Question 42 of 60
Natural killer (NK) cells are excellent killers of cells infected by some They also have an additional role of stimulating the immune response.
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Question 43 of 60
Most cases of septic shock are caused by gram organisms with the acting as the endotoxin in the disease.
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ATI RN · Pediatric Immunity NCLEX Questions
Question 44 of 60
MHC molecules exhibit and immunoglobulin/TCR molecules exhibit
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Question 45 of 60
A young patient presents with severe infections from encapsulated bacteria and collagen vascular disease. Lab work confirms a diagnosis via CH50 and AP50. Which of the following is the most likely?
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Question 46 of 60
What is the major site for hematopoiesis, where all blood cells are formed?
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Question 47 of 60
A patient presents with symptoms similar to DiGeorge's syndrome. It is determined that the patient's TH cells are unable to develop. Which of the following is the most likely?
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Question 48 of 60
Which of the following is NOT true?
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Question 49 of 60
Mucociliary escalator
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Question 50 of 60
Where are δγ T cells generally found in the body (location of TCR rearrangement)?
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Question 51 of 60
Which of the following statements best applies to the following diagram?
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Question 52 of 60
Expression of L-selectin (CD62L), the receptor that facilitates homing of peripheral lymph nodes, is ___ for memory T cells, ___ for naïve T cells, and ___ for effector T cells.
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Question 53 of 60
which of the following is a transcriptional factor for immune genes
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Question 54 of 60
When a human pathogen is repeatedly grown and passaged in cells of a different species and then used for vaccination purposes, the resulting vaccine is referred to as a/an...?
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Question 55 of 60
The structure of the B-cell receptor contains the invariant proteins Iga and Ig β, which are linked via and are essential for signal generation across the B-cell surface membrane and for surface expression of immunoglobulin receptors (mIgs).
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Question 56 of 60
Long-term effective therapy for the patient described in Question 2 is best accomplished with
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Question 57 of 60
The complement component of both the classical and alternative pathways is
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Question 58 of 60
Wrong about neutrophils
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Question 59 of 60
During the final step of synthesis for heavy and light immunoglobulin chains, which of the following peptides is cleaved?
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Question 60 of 60
Pancreatic insufficiency, metaphyseal chondrodysplasia, autosomal recessive inheritance, defective chemotaxis, and neutropenia are features of
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