Pediatric Immune Disorder Test Questions

ATI RN · Pediatric Immune Disorder Test Questions

Question 1 of 58

A 40-day-old, previously healthy, fullterm female infant manifests fever, lethargy, and poor feeding for 12 hours. Physical examination reveals a lethargic child with vital signs of RR 70, HR 185, BP mean 25, T 39.50Ã‚Â°C. The peripheral perfusion is poor, the chest reveals retractions, the abdomen is soft and reveals persistence of the umbilical cord, and the extremities are cool. Laboratory studies reveal a white blood cell count of 65,000 and a platelet count of 105,000. Family history reveals that a male sibling died suddenly at the age of 2 months, 10 years prior to the birth of this child. The most likely diagnosis is

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ATI RN · Pediatric Immune Disorder Test Questions

Question 2 of 58

In the alternative complement pathway, this component molecule undergoes spontaneous activation, which creates a challenge for organ xenotransplantation.

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ATI RN · Pediatric Immune Disorder Test Questions

Question 3 of 58

The response time to antigenic stimulation for memory B and T cells is described as ___, for naÃ¯ve B and T cells is described as ___, and for effector B and T cells is described as ___

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ATI RN · Pediatric Immune Disorder Test Questions

Question 4 of 58

IFN-Î³ stimulates ___ immunity by enhancing ___ T cells as well as activating macrophages and natural killer cells. IL-4/IL-5 stimulate ___ immunty (antibodies) by activating B cells and eosinophils and induce ___-type responses.

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ATI RN · Pediatric Immune Disorder Test Questions

Question 5 of 58

Which of the following types of antigen presenting cells (APCs) has immunoglobulin that functions as a receptor, then the antigen is internalized, degraded, and presented to T cells?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 6 of 58

Which of the following BEST describes cytokines?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 7 of 58

At what stage are rearranged TCRs expressed on the cell surface?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 8 of 58

Which of the following live vaccines is recommended for children but not adults?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 9 of 58

During B cell development, at what stage is membrane bound IgM found?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 10 of 58

which of the following cells is not from a myeloid origin

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ATI RN · Pediatric Immune Disorder Test Questions

Question 11 of 58

A 5-month-old infant presented with reluctance to feed, lethargy, abdominal distension, and severe gingivitis. The parents are healthy relatives and gave history of non-purulent omphalitis with separation of umbilical stump at the age of 2 months. His peripheral smear showed neutrophil count 24,000/mm3. Of the following, the MOST likely diagnosis is

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ATI RN · Pediatric Immune Disorder Test Questions

Question 12 of 58

Only has fragment antigen-binding (Fab) region

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ATI RN · Pediatric Immune Disorder Test Questions

Question 13 of 58

Which of the following is often asymptomatic to presenting with an increased incidence of respiratory tract infections and is the most common immunodeficiency disease?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 14 of 58

A medical student wants to perform a study on MACROPHAGES type 1, the best way to get these cells is by

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ATI RN · Pediatric Immune Disorder Test Questions

Question 15 of 58

The spleen has a red pulp (macrophages and red blood cells) and a white pulp (dense lymphoid tissue). T cells are found chiefly in the and B cells are found in the both within the pulp.

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ATI RN · Pediatric Immune Disorder Test Questions

Question 16 of 58

Which one of the following is NOT a primary function of phagocytes?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 17 of 58

The biochemical structure of the T-cell receptor (TCR) of theÎ±Î² type (95% of human TCRs) is comparable to a immunoglobulin fragment, having very short cytoplasmic tails.

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ATI RN · Pediatric Immune Disorder Test Questions

Question 18 of 58

A male infant presents with a triad of symptoms including thrombocytopenia, eczema, and immunodeficiency. Which of the following is the most likely?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 19 of 58

Bacteria such as Mycobacterium tuberculosis have acquired the capacity to inhibit phagosome-lysosome fusion. What is a consequence of this?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 20 of 58

What types of cell is class I MHC found on?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 21 of 58

lymphocytes migrate to and lodge in selected tissue sites (lymphocyte homing). constantly circulate among the lymphoid organs until they encounter antigen or die.

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ATI RN · Pediatric Immune Disorder Test Questions

Question 22 of 58

The T cell-APC interaction is MHC -restricted, and the T cell-target cell interaction is MHC -restricted.

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ATI RN · Pediatric Immune Disorder Test Questions

Question 23 of 58

The virus in the above question spreads from the respiratory tract and causes viremia. Which antibody class would be most important in fighting the virus as it spreads through the body?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 24 of 58

Antigen recognition molecule

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ATI RN · Pediatric Immune Disorder Test Questions

Question 25 of 58

Which of the following Antibodies occurs as a pentameric structure?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 26 of 58

Matching: Immunodeficiency - Chromosome 22q12

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ATI RN · Pediatric Immune Disorder Test Questions

Question 27 of 58

Which of the following C1 subunit has the catalytic activity that cleaves C4 and C2 complement proteins?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 28 of 58

Protein tyrosine kinases (PTKs) play an important role in lymphocyte function and activation. A mutation in the genes encoding the enzyme ZAP-70 would lead to which of the following?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 29 of 58

How are B-cell and T-cell antigen receptors distributed?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 30 of 58

Failure to thrive, diarrhea, malabsorption, and infections with opportunistic infections (i.e., fungi, Candida sp, Pneumocystis jiroveci [carinii]) suggest

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ATI RN · Pediatric Immune Disorder Test Questions

Question 31 of 58

Critical in antigen-capture and uptake in peripheral tissues

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ATI RN · Pediatric Immune Disorder Test Questions

Question 32 of 58

Di George syndrome results from a defect in?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 33 of 58

Most common cause of secondary immunodeficiency?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 34 of 58

Which of the following is NOT true of neutrophils compared with macrophages?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 35 of 58

Where does affinity maturation occur?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 36 of 58

Endothelial cells expresses glycoprotein that binds with low affinity to WBCs and helps in their recruitment from blood to tissues

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ATI RN · Pediatric Immune Disorder Test Questions

Question 37 of 58

What is the phagocytic defect of chronic granulomatous disease?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 38 of 58

Systemic lupus erythematosus

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ATI RN · Pediatric Immune Disorder Test Questions

Question 39 of 58

Which of the following is NOT true regarding eosinophils?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 40 of 58

Which of the following diseases affect neutrophils?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 41 of 58

The two types of light chains are:

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ATI RN · Pediatric Immune Disorder Test Questions

Question 42 of 58

Which of the following MHC class II genes has the least alleles?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 43 of 58

All the following matching about genetic deficiencies of plasma complement components and associated clinical findings are true EXCEPT

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ATI RN · Pediatric Immune Disorder Test Questions

Question 44 of 58

Which of the following uses ultraviolet (UV) light for examining specimens?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 45 of 58

Which of the following are early clinical signs of (septic) shock?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 46 of 58

Atopic people produce an increased amount of IgE. Of the following, which is the most likely explanation for the increased amount of IgE?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 47 of 58

If both RAG-1 and RAG-2 mutations occur, which of the following is true?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 48 of 58

Leukemoid reactions (WBC count >50,000/Î¼L) are caused by all the following EXCEPT

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ATI RN · Pediatric Immune Disorder Test Questions

Question 49 of 58

The currently available vaccine to prevent hepatitis A infection is...?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 50 of 58

Which of the following components of the adaptive immune system causes lysis of virally infected cells and the release of cytokines?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 51 of 58

Severe neutropenia is defined as absolute neutrophil count (ANC) less than

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ATI RN · Pediatric Immune Disorder Test Questions

Question 52 of 58

IgM is structurally characterized as:

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ATI RN · Pediatric Immune Disorder Test Questions

Question 53 of 58

Initially prevent organism penetration

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ATI RN · Pediatric Immune Disorder Test Questions

Question 54 of 58

The initial screening laboratory evaluation of a child with recurrent infections for possible immunodeficiency includes all of the following EXCEPT

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ATI RN · Pediatric Immune Disorder Test Questions

Question 55 of 58

If a person had a genetic defect affecting perforin production, which cells and immune function would be affected?

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ATI RN · Pediatric Immune Disorder Test Questions

Question 56 of 58

The MOST appropriate method to correct the immune deficiency in complete DiGeorge syndrome is

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ATI RN · Pediatric Immune Disorder Test Questions

Question 57 of 58

The most likely diagnosis in the patient described in Question 2 is

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ATI RN · Pediatric Immune Disorder Test Questions

Question 58 of 58

Depressed levels of MHC class I molecules on virus infected host cells can be detected by

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