The spleen, the major filter for blood, is about the size of a clenched fist and is found on the side associated posteriorly with ribs
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Question 3 of 58
B cells whose BCRs bind antigen with high-affinity receive survival signals (called selection) from follicular dendritic cells (FDCs) and germinal center T cells, whereas those that fail to bind antigen
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Question 4 of 58
Which of the following best describes the affinity of antibody secreted for effector B cells?
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Question 5 of 58
Which of the following is least important in fighting extracellular pathogen
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Question 6 of 58
Protein and nucleic acid sequence data have been obtained for many TCRs with different specificities. Analyses of these sequences suggest the existence of how many hypervariable (hv) regions within the variable region?
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Question 7 of 58
The viral infection in the above question began in the respiratory tract. Which antibody class would best protect respiratory epithelial cells from viral infection?
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ATI RN · NCLEX Pediatric Immunization Questions
Question 8 of 58
Rhesus D hemolytic disease of the newborn is classified as...?
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Question 9 of 58
In somatic recombination, the rearranges first. The region of the antibody molecule is generated via somatic recombination as it binds to the antigen and contains both a constant region and a variable region.
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Question 10 of 58
A protein of herpes simplex virus (HSV) binds to TAP and inhibits peptide transport into the endoplasmic reticulum. What is a consequence of this?
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Question 11 of 58
Which of the following MHC class II genes has the most alleles (most polymorphic)?
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Question 12 of 58
neonate immunity is mainly by
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Question 13 of 58
Papain cleaves what region of immunoglobulin?
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Question 14 of 58
A 7-year-old child presented with severe stridor and abdominal pain, he gives history of recurrent episodes of nonpruritic edema lasting 48 to 72 hours, which usually triggered by stress, or anxiety. Of the following, the MOST effective treatment is
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Question 15 of 58
Evaluations of immune function should be initiated for otherwise healthy children with which of the following infections?
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Question 16 of 58
Which of the following components of the adaptive immune system secretes immunoglobulin (Ig)?
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Question 17 of 58
Which of the following is used to characterize antigens in complex mixtures biochemically?
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Question 18 of 58
What structural feature is uniquely found on IgA in breast milk and not found on serum IgM?
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Question 19 of 58
A 15-month-old child presented with repeated skin and pulmonary infections started shortly after birth, his blood film showed severe neutropenia with impressive monocytosis, he is the third sibling of a first cousin healthy parents, the second sibling had the same problem and died due to acute myeloid leukemia. Of the following, the MOST likely diagnosis is
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Question 20 of 58
Which of the following would NOT act initially during mast cell (or basophil) activation?
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Question 21 of 58
Regarding the cutaneous immune system (skin), T lymphocytes and Langerhans cells (chiefly ) are found in the and macrophages and T cells are found in the
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Question 22 of 58
Which of the following is NOT true about live vaccines?
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Question 23 of 58
Which of the following component molecules is activated in the classical pathway after binding to an Fc?
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Question 24 of 58
The genes encoding which of the following are extensively polymorphic (have multiple alleles or forms of the same gene)?
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Question 25 of 58
Leukemoid reactions (WBC count >50,000/μL) are characterized by abundant
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Question 26 of 58
Which of the following describes this image?
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Question 27 of 58
X-linked agammaglobulinemia results from a mutation in?
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Question 28 of 58
Leukocyte-specific protein tyrosine kinase (Lck) is integral in the signaling cascade in cells. Zeta-chain-associated protein kinase 70 (ZAP-70), which binds CD3-zeta, is cell specific. Spleen tyrosine kinase (Syk), a signal transmitter, is found predominantly in cells.
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Question 29 of 58
An anti-inflammatory cytokine is a
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Question 30 of 58
B and T cells are produced by stem cells that are in:
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Question 31 of 58
Which of the following is not typically associated with an eosinophilic response and eosinophilia?
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ATI RN · NCLEX Pediatric Immunization Questions
Question 32 of 58
Matching: Immunodeficiency - Splenomegaly
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Question 33 of 58
Which of the following are secreted by macrophages after they have recognized pathogens using pattern recognition molecules (induction phase)?
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Question 34 of 58
Pattern recognition receptors (PRR) can be found on
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Question 35 of 58
Surfactants, pathogen binding collectins
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Question 36 of 58
Which of the following best describes penicillin, a hapten?
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Question 37 of 58
Which of the following diseases occurs with the absence of a thymus?
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Question 38 of 58
Combat certain parasitic infections (e.g. worms); hydrolytic enzymes
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Question 39 of 58
A patient presents at 3-years-old for a follow-up visit. At age 6-months, the patient had a delayed onset of synthesis of an immunoglobulin. At this visit, the mother reports that the recurrent respiratory infections have stopped due to antibiotics and globulin replacement. Which of the following was the most likely for this patient?
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Question 40 of 58
Binds to various cellular receptors and to complement
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Question 41 of 58
Type II Hypersensitivity...?
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Question 42 of 58
Pemphigus vulgaris
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Question 43 of 58
Which of the following types of antigen presenting cells (APCs) is critical in uptake and presentation of antigen to T cells?
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Question 44 of 58
A 6-year-old presents with the appearance of being intoxicated while walking. Opthlamoscopic findings reveal broken capillaries in the sclera of the eye. Lab work reveals IgA deficiency. Which of the following is the most likely?
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Question 45 of 58
The highest white blood cells count is seen at
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Question 46 of 58
Dendritic cells, macrophages, and what other cell types are considered 'professional antigen presenting cells,' capable of antigen presentation to T helper cells?
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Question 47 of 58
Cytokines produced by TH1 are ___ (microbial infection response) and cytokines produced by TH2 are ___ (parasitic infection response and allergy response).
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Question 48 of 58
Of the following, the findings that are MOST suggestive of DiGeorge syndrome are
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Question 49 of 58
During B cell development, at what stage can cytoplasmic μ chains begin to be found?
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Question 50 of 58
Adhesion molecule
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Question 51 of 58
The major components of host defense include anatomic barriers and the innate and adaptive immune systems. The adaptive immune system is made up of
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Question 52 of 58
which of the following Receptors is not found as membrane bound or endothelial bound receptors in MACROPHAGES
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Question 53 of 58
Deficiencies in lead to autosomal-recessive severe combined immunodeficiency disease (SCID).
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Question 54 of 58
A 5-year-old boy presents with his third episode of painful cervical lymphadenitis. Each was treated with incision and drainage and grew Staphylococcus aureus. At the age of 2 years, he required surgical aspiration of a liver abscess. The most important laboratory test is
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Question 55 of 58
Which of the following begins at the DP stage and not the DN stage?
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Question 56 of 58
Which of the following is NOT true of T-cell receptors, when compared to immunoglobulin?
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Question 57 of 58
In the classical pathway, the antibody activated the C1 complex consisting of C1q, C1r & C1s subunit. Which of the following subunit binds to the antibody
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Question 58 of 58
All the following are characteristic in properdin deficiency EXCEPT
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