A parent of a 4-year-old with suspected Wilms tumor is brought to the clinic. Which is most important during the physical examination?
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Question 2 of 54
The best assessment of iron overload for patients with thalassemia major is achieved by
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Question 3 of 54
One of the following features DOES NOT fit von-Willebrand disease
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Question 4 of 54
A child receiving a transfusion of packed red blood cells develops signs of a hemolytic reaction. Which of the following would be expected? (Select one that does not apply.)
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Question 5 of 54
Beside pallor, the MOST common presentation of sickle cell disease during infancy is
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Question 6 of 54
A 1-year-old child has folic acid deficiency since the age of 4 months, the best indicator of this deficiency is
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Question 7 of 54
Matching: Hemolytic anemia - Oxidant stressors
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Question 8 of 54
In the patient described in Questions 10 and 11, when the hemoglobin and hematocrit return to normal, which should be done?
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Question 9 of 54
Matching: Regional lymphadenopathy - Rubella
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Question 10 of 54
Which measure should be implemented for a child with von Willebrand disease who has a nosebleed?
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Question 11 of 54
Which of the following can lead to a possible diagnosis of human immunodeficiency virus (HIV) in a child? (Select one that does not apply.)
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Question 12 of 54
Which of the following symptoms/signs is a manifestation of polycythemia?
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Question 13 of 54
A 28-year-old black man with sickle cell disease presents to the emergency department with abdominal pain, chest pain, and shortness of breath. His dyspnea evolved over 36 hours after a visit with his niece and nephew. His history is significant for approximately 2 emergency department visits or hospital admissions per year for painful crises. Three years ago, he spent 4 weeks in the hospital after an episode of acute chest syndrome. He has been taking hydroxyurea but only intermittently because of financial concerns. His pulse is 116 beats per minute and regular, his blood pressure is 138/76 mm Hg, his respiratory rate is 18 breaths per minute, and his temperature is 38.3°C. Pulse oximetry shows 91% oxygen saturation with room air and 93% with 4 L of oxygen by nasal cannula. His lungs have scattered inspiratory crackles in the right midlung field. His spleen is not palpable. The remainder of the physical examination findings are normal. Diagnostic testing results are shown in Table 9.Q4. A chest radiograph shows a right middle and upper lobe air space infiltrate. The patient is given supplemental oxygen, adequate pain control, and intravenous antibiotics. Which of the following should you now order?
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Question 14 of 54
Which of the following is the best treatment for a 5-year-old girl with acute immune thrombocytopenia (ITP) and platelets count of $30,000 / \mathrm{ml}$ and mild petechial rash all over her body?
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Question 15 of 54
A 9-year-old male child is about to do elective tonsillectomy; preoperative investigations are all normal except for a significant prolonged partial thromboplastin time PTT; there was no previous bleeding after circumcision and emergency appendectomy. Of the following, the MOST likely diagnosis is
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Question 16 of 54
The LEAST helpful historical clue in Iron deficiency anemia is
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Question 17 of 54
The main stay of treatment for congenital hypoplastic anemia is
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Question 18 of 54
A 9-month-old child with a hemoglobin concentration of $10 \mathrm{gm} / \mathrm{dL}$ and marked microcytosis; serum iron and total iron binding capacity are within normal limits; serum ferritin and hemoglobin electrophoresis are also normal. Of the following, the MOST likely diagnosis is
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Question 19 of 54
Which best describes the action of chemotherapeutic agents used in treating cancer in children?
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Question 20 of 54
Prednisone is given to children being treated for leukemia. Why is this medication included in the treatment plan?
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Question 21 of 54
Arterial thrombosis is the least likely cause of
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Question 22 of 54
Fragmentation hemolysis by mechanical injury may be seen in all the following EXCEPT
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Question 23 of 54
Splenectomy is recommended in all the following conditions EXCEPT
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Question 24 of 54
At her annual physical examination, an asymptomatic 68-year-old woman has lymphocytosis (32 × 10^9/L) with a normal hemoglobin level and platelet count. On examination, she has 1-cm lymphadenopathy in the cervical region and no palpable liver or spleen enlargement. A peripheral blood smear shows identically appearing mature lymphocytes with smudge cells. Flow cytometry of the peripheral blood lymphocytes shows a monoclonal B population with dim expression of λ light chain and CD20 that is positive for expression of CD5, CD19, and CD23. Which of the following is the best next step in her management?
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Question 25 of 54
In severe liver disease with prolongation of the bleeding time, the best effective treatment before doing liver biopsy is
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Question 26 of 54
Matching: Red blood cell aplasia - Rarely needs multiple transfusions
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Question 27 of 54
You are explaining the risk of sepsis after splenectomy to medical students. An important statement that should be included during this discussion is that risk is especially high in children
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Question 28 of 54
Which are the reasons to perform a lumbar puncture on a child with leukemia? (Select one that does not apply..)
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Question 29 of 54
Appropriate long-term management of the disease described in Question 3 includes all of the following EXCEPT
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Question 30 of 54
A child with hemophilia A fell and injured a knee while playing outside. The knee is swollen and painful. Which of the following measures should be taken to stop the bleeding? (Select one that does not apply.)
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Question 31 of 54
The definitive diagnostic test for the condition described in Question 19 is
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Question 32 of 54
Vitiligo, glossitis, ataxia, and peripheral neuropathy are features of
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Question 33 of 54
Which of the following conditions affects partial thromboplastin time?
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Question 34 of 54
Which laboratory test is most likely abnormal in a child with hemophilia?
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Question 35 of 54
The best clinical indicator of ongoing hemolysis in G6PD is
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Question 36 of 54
An illogical cause of failure of increment of hemoglobin after starting treatment of iron deficiency anemia is
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Question 37 of 54
A 45-year-old man presents with deep vein thrombosis of the right femoral vein. Three months ago, he received a diagnosis of systemic lupus erythematosus (SLE). In addition to confirming SLE, laboratory testing also documented the presence of a lupus anticoagulant (LAC). There is no family history of venous thrombosis. Current medications include hydroxychloroquine. Laboratory testing shows normal results for a complete blood cell count and for tests of liver and kidney function. Special coagulation testing confirms the persistence of an LAC. What is the most reasonable duration of warfarin anticoagulation for this patient?
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Question 38 of 54
Iron deficiency anemia is less prevalent in breast fed infants because
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Question 39 of 54
A 10-year-old undergoes total splenectomy because of trauma. The best statement about the risk of postsplenectomy infection is that
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Question 40 of 54
Fresh frozen plasma (FFP) transfusion/replacement is indicated in all the following conditions EXCEPT
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Question 41 of 54
In disseminated intravascular coagulation, which of the followings is reduced?
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Question 42 of 54
A child with sickle cell disease is scheduled to have a splenectomy. What is the primary reason for this surgery?
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Question 43 of 54
Which of the following drugs is least likely to cause thrombocytopenia in children?
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Question 44 of 54
A 3.2-kg, 40-week's-gestational age male is born by spontaneous vaginal delivery to a 20-year-old white female. Past maternal medical problems reveal a history of easy bruising that required splenectomy at 18 years of age. Current coagulation studies of the mother include a prothrombin time of 12 seconds, a partial thromboplastin time of 25 seconds, fibrinogen of 300 mg/dL, and a platelet count of 175,000. At 3 hours of age, the infant is noted to have multiple petechiae and a platelet count of 15,000. The most likely diagnosis is
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Question 45 of 54
A 2-year- old boy presented with recurrent skin and respiratory tract infections since early infancy, he had abnormally eczematous skin of the upper and lower limbs. His initial tests showed normal liver and renal functions with CBC showing low platelets count. He has similarly affected male cousin. Of the following, the MOST likely diagnosis is
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Question 46 of 54
The LEAST confirmatory finding of ABO compatibility in a 2-day- old newborn is
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Question 47 of 54
A nurse is caring for a 5-year-old with sickle cell vaso-occlusive crisis. Which of the following orders should the nurse question?
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Question 48 of 54
Which of the following hemoglobinopathies is transfusion dependent?
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Question 49 of 54
A 5-year-old child has multiple bruises on her extremities and oral mucosal bleeding of 3 days duration; she had a mild respiratory tract infection 2 weeks before; physical examination was normal apart from multiple ecchymoses and petechiae. Of the following, the NEXT diagnostic step is
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Question 50 of 54
A 3-year-old male child develops hematoma and bruising of his right hand next day after falling on the ground; the mother stated that her child has a poor wound healing and a history of delayed umbilical separation during the neonatal period. Of the following, the MOST valuable test for this case is
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Question 51 of 54
Which of the following results correctly fits the expected transfusion outcome?
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Question 52 of 54
A 73-year-old woman presented to the emergency department with new-onset back pain, confusion, and constipation over the past week. Her past medical history is significant only for hypertension. On examination, she is slightly pale with slow cognition and point tenderness over the lumbar spine. Plain films of the lumbar spine show osteolytic lesions in L2, L3, and L5. Laboratory values are as follows: hemoglobin 9.3 g/dL, leukocyte count 4.6 × 10^9/L with a normal differential count, platelet count 230 × 10^9/L, creatinine 1.6 mg/dL, total calcium 13.1 mg/dL, albumin 3.6 g/dL, and total protein 9.1 g/dL. What is the most likely diagnosis?
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Question 53 of 54
A previously healthy 10-month-old boy develops pallor over 2 weeks. Examination is unremarkable except for pallor. Lab tests includes: hemoglobin, 4.9 g/dL; WBC, 6700/mm3; platelets count, 180000/mm3; MCV, 79 fL; reticulocyte count 0.8%; hemoglobin electrophoresis, normal. Of the following, the MOST likely cause for these findings is
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Question 54 of 54
When caring for a child with lymphoma, the nurse should be aware that:
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